Angel Correa scored twice just before half-time, heading in from close range and then stabbing home Yannick Carrasco’s pass.
Carrasco made it three when he beat the offside trap before he and Correa each teed up Marcos Llorente for a double of his own.
Diego Simeone’s side stay top, ahead of rivals Real with seven games to play.
Atletico’s title charge has stumbled in recent weeks and injuries to key players Luis Suarez and Joao Felix have left them light in attack.
But Correa’s first goals since February gave them a platform and they cut loose after the break.
In a compelling La Liga title race, Atletico have their destiny in their own hands but may need to win all their remaining games to secure top spot.