Kane, 27, needed treatment on his left ankle after landing awkwardly following a challenge with Jordan Henderson.
The England captain also hurt his right ankle in an earlier challenge with Liverpool midfielder Thiago Alcantara.
The striker, who has a history of ankle issues, continued before being replaced by Erik Lamela at half-time.
The second injury was worse than the first one, He was coping with one but couldn’t cope with both.
For Harry to leave a game when the team is losing is not a nothing injury.
There are some players you can’t replace. When it happens it happens, but I believe we have to fight against it, we cannot do anything else.